Tuesday, September 3, 2019

Poor Diet Can Lead to Blindness



An extreme case of "fussy" or "picky" eating caused a young patient’s blindness, according to a new case report published  [2 Sep 2019] in Annals of Internal Medicine. The University of Bristol researchers who examined the case recommend clinicians consider nutritional optic neuropathy in any patients with unexplained vision symptoms and poor diet, regardless of BMI, to avoid permanent vision loss.

Nutritional optic neuropathy is a dysfunction of the optic nerve which is important for vision. The condition is reversible, if caught early. But, left untreated, it can lead to permanent structural damage to the optic nerve and blindness.

Credit: University of Bristol

In developed countries like the UK, the most common causes of nutritional optic neuropathy are bowel problems or drugs that interfere with the absorption of various important nutrients from the stomach. Purely dietary causes are less common because food supply is good, but elsewhere in the world, poverty, war and drought are linked to malnutrition and higher rates of nutritional optic neuropathy.

Clinician scientists from Bristol Medical School and the Bristol Eye Hospital examined the case of a teenage patient who first visited his GP complaining of tiredness. The link between his nutritional status and vision was not picked up until much later, and by then, his visual impairment had become permanent.

Aside from being a “fussy eater,” the patient had a normal BMI and height and no visible signs of malnutrition and took no medications. Initial tests showed macrocytic anaemia and low vitamin B12 levels, which were treated with vitamin B12 injections and dietary advice. When the patient visited the GP a year later, hearing loss and vision symptoms had developed, but no cause was found. By age 17, the patient’s vision had progressively worsened, to the point of blindness. Further investigation found the patient had vitamin B12 deficiency, low copper and selenium levels, a high zinc level, and markedly reduced vitamin D level and bone mineral density. Since starting secondary school, the patient had consumed a limited diet of chips, crisps, white bread, and some processed pork. By the time the patient’s condition was diagnosed, the patient had permanently impaired vision.

The researchers concluded that the patient’s ‘junk food’ diet and limited intake of nutritional vitamins and minerals resulted in the onset of nutritional optic neuropathy. They suggest the condition could become more prevalent in future, given the widespread consumption of ‘junk food’ at the expense of more nutritious options, and the rising popularity of veganism if the vegan diet is not supplemented appropriately to prevent vitamin B12 deficiency.

Dr Denize Atan, the study’s lead author and Consultant Senior Lecturer in Ophthalmology at Bristol Medical School and Clinical Lead for Neuro-ophthalmology at Bristol Eye Hospital, said: “Our vision has such an impact on quality of life, education, employment, social interactions, and mental health. This case highlights the impact of diet on visual and physical health, and the fact that calorie intake and BMI are not reliable indicators of nutritional status.”

The team recommend dietary history should be part of any routine clinical examination like asking about smoking and alcohol intake. This may avoid a diagnosis of nutritional optic neuropathy being missed or delayed as some associated visual loss can fully recover if the nutritional deficiencies are treated early enough.

About nutritional optic neuropathy

Our eyes are responsible for detecting different patterns and wavelengths (colours) of light and this information is sent to our brain via the optic nerve. Each time you visit an optometrist and they "look inside/behind your eyes", they are examining the optic nerves to check their health. Optic neuropathy is the medical term for damage to the optic nerve. If the damage is caused by poor nutrition it is referred to as "nutritional optic neuropathy".

Nutritional optic neuropathy is an uncommon but serious complication of a number of different types of nutritional deficiency. And nutritional deficiencies are extremely common. It is estimated that nutritional deficiencies affect approximately 2-billion people worldwide. In low- and middle-income countries, poverty and inadequate food intake are the main causes of micronutrient deficiencies, but micronutrient deficiencies also exist in high-income countries like the UK.

Deficiencies of vitamin B1 (thiamine), vitamin B2 (riboflavin), vitamin B3 (niacin), vitamin B6(pyridoxine), vitamin B9 (folate), vitamin B12 (cobalamin), iron, calcium, magnesium, and copper are all known to cause optic neuropathy, and are easily misdiagnosed as other disorders without an adequate dietary history from the patient.


Contacts and sources:
University of Bristol

Citation: ‘Case report on blindness due to a junk food diet’
Rhys Harrison, Vicki Warburton, Andrew Lux, Denize Atan. Annals of Internal Medicine, 2019; DOI: 10.7326/L19-0361




1 comment:

  1. Great work man i would like to congratulate you on this effort GNLD

    ReplyDelete