Wednesday, August 22, 2018

Neandertal Mother, Denisovan Father: Mixing Among Archaic Humans Was Common


"Neanderthals and Denisovans are extinct groups of hominins that separated from each other more than 390,000 years ago."

Up until 40,000 years ago, at least two groups of hominins inhabited Eurasia – Neandertals in the west and Denisovans in the east. Now, researchers at the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, sequenced the genome of an ancient hominin individual from Siberia, and discovered that she had a Neandertal mother and a Denisovan father.

"The finding of a first-generation Neanderthal–Denisovan offspring among the small number of archaic specimens sequenced to date suggests that mixing between Late Pleistocene hominin groups was common when they met."

This bone fragment (“Denisova 11”) was found in 2012 at Denisova Cave in Russia by Russian archaeologists and represents the daughter of a Neandertal mother and a Denisovan father. 

Credit:  © T. Higham, University of Oxford

Together with their sister group the Neandertals, Denisovans are the closest extinct relatives of currently living humans. “We knew from previous studies that Neandertals and Denisovans must have occasionally had children together”, says Viviane Slon, researcher at the Max Planck Institute for Evolutionary Anthropology and one of three first authors of the study. “But I never thought we would be so lucky as to find an actual offspring of the two groups.”

The ancient individual is only represented by a single small bone fragment. “The fragment is part of a long bone, and we can estimate that this individual was at least 13 years old”, says Bence Viola of the University of Toronto. The bone fragment was found in 2012 at Denisova Cave (Russia) by Russian archaeologists. It was brought to Leipzig for genetic analyses after it was identified as a hominin bone based on its protein composition.

“An interesting aspect of this genome is that it allows us to learn things about two populations – the Neandertals from the mother’s side, and the Denisovans from the father’s side”, explains Fabrizio Mafessoni from the Max Planck Institute in Leipzig who co-authored the study. The researchers determined that the mother was genetically closer to Neandertals who lived in western Europe than to a Neandertal individual that lived earlier in Denisova Cave. This shows that Neandertals migrated between western and eastern Eurasia tens of thousands of years before their disappearance.


View of the valley from above the Denisova Cave archaeological site, Russia.

Credit: © B. Viola, MPI f. Evolutionary Anthropology

Analyses of the genome also revealed that the Denisovan father had at least one Neandertal ancestor further back in his family tree. “So from this single genome, we are able to detect multiple instances of interactions between Neandertals and Denisovans”, says Benjamin Vernot from the Max Planck Insitute, the third co-author of the study.

“It is striking that we find this Neandertal/Denisovan child among the handful of ancient individuals whose genomes have been sequenced”, adds Svante Pääbo, Director of the Department of Evolutionary Genetics at the Leipzig Max Planck Institute and lead author of the study. “Neandertals and Denisovans may not have had many opportunities to meet. But when they did, they must have mated frequently – much more so than we previously thought.”


Contacts and sources:
Sandra Jacob
The Max Planck Institute for Evolutionary Anthropology

Citation:
The genome of the offspring of a Neanderthal mother and a Denisovan father
Viviane Slon, Fabrizio Mafessoni, Benjamin Vernot, Cesare de Filippo, Steffi Grote, Bence Viola, Mateja Hajdinjak, Stéphane Peyrégne, Sarah Nagel, Samantha Brown, Katerina Douka, Tom Higham, Maxim B. Kozlikin, Michael V. Shunkov, Anatoly P. Derevianko, Janet Kelso, Matthias Meyer, Kay Prüfer & Svante Pääbo
Nature (2018)https://www.nature.com/articles/s41586-018-0455-x

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