Sunday, November 30, 2014

Wi-Fi Drug Delivery: Wireless Electronic Implants Stop Staph, Then Harmlessly Dissolve

Researchers at Tufts University, in collaboration with a team at the University of Illinois at Champaign-Urbana, have demonstrated a resorbable electronic implant that eliminated bacterial infection in mice by delivering heat to infected tissue when triggered by a remote wireless signal.  The silk and magnesium devices then harmlessly dissolved in the test animals. The technique had previously been demonstrated only in vitro.
Credit: Tufts University

 The research is published online in the Proceedings of the National Academy of Sciences Early Edition the week of November 24-28, 2014.

"This is an important demonstration step forward for the development of on-demand medical devices that can be turned on remotely to perform a therapeutic function in a patient and then safely disappear after their use, requiring no retrieval," said senior author Fiorenzo Omenetto, professor of biomedical engineering and Frank C. Doble professor at Tufts School of Engineering. "These wireless strategies could help manage post-surgical infection, for example, or pave the way for eventual 'wi-fi' drug delivery."

Optical (and corresponding IR) images of the dissolution of implant device (top row: powering induction coil with resistor/heater) 

Credit: Tufts University

Implantable medical devices typically use non-degradable materials that have limited operational lifetimes and must eventually be removed or replaced. The new wireless therapy devices are robust enough to survive mechanical handling during surgery but designed to harmlessly dissolve within minutes or weeks depending on how the silk protein was processed, noted the paper's first author, Hu Tao, Ph.D., a former Tufts post-doctoral associate who is now on the faculty of the Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences.

Each fully dissolvable wireless heating device consisted of a serpentine resistor and a power-receiving coil made of magnesium deposited onto a silk protein layer. The magnesium heater was encapsulated in a silk "pocket" that protected the electronics and controlled its dissolution time.

Devices were implanted in vivo in S. aureus infected tissue and activated by a wireless transmitter for two sets of 10-minute heat treatments. Tissue collected from the mice 24 hours after treatment showed no sign of infection, and surrounding tissues were found to be normal. Devices completely dissolved after 15 days, and magnesium levels at the implant site and surrounding areas were comparable to levels typically found in the body.

The researchers also conducted in vitro experiments in which similar remotely controlled devices released the antibiotic ampicillin to kill E. coli and S. aureus bacteria. The wireless activation of the devices was found to enhance antibiotic release without reducing antibiotic activity.

Omenetto holds an adjunct appointment in the Department of Physics in the School of Arts and Sciences at Tufts as well as appointments in the Departments of Biomedical Engineering and Chemical and Biological Engineering in the School of Engineering.


Contacts and sources:
Kim Thurler
Tufts University


In addition to Omenetto and Tao, authors on the paper were co-first author Suk-Won Hwang, formerly of the Department of Materials Science and Engineering, Beckman Institute for Advanced Science and Technology, and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, and now at KU-KIST Graduate School of Converging Science and Technology, Korea University; Benedetto Marelli, Bo An, Jodie E. Moreau, Miaomiao Yang, and Mark A. Brenckle, Department of Biomedical Engineering, Tufts University; Stanley Kim, Department of Materials Science and Engineering, Beckman Institute for Advanced Science and Technology, and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign; David L. Kaplan, Department of Biomedical Engineering and Department of Chemical and Biomedical Engineering, Tufts University; and co-corresponding author John A. Rogers, Department of Materials Science and Engineering, Beckman Institute for Advanced Science and Technology, Frederick Seitz Materials Research Laboratory, Department of Chemistry, and Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign.

Research reported in this paper was supported by the National Institutes of Health under award number P41-EB002520 and by the National Science Foundation under grant number DMR-1242240.

Citation: "Silk-based resorbable electronic devices for remotely controlled therapy and in vivo infection abatement," http://www.pnas.org/cgi/doi/10.1073/pnas.1407743111
 

2 comments:

  1. Wow!That's quite interesting. Thanks for your help. I prefer latest updated featured portable wind meters for measuring weather because it's much more advance.

    ReplyDelete
  2. In the event that you have moved clasps around utilizing a magnet, at that point you have fiddled with the standards behind the most complex electric generators.topgeneratorreview

    ReplyDelete