Friday, May 3, 2013

Cure For Gray Hair Coming: Gray Hair And Vitiligo Reversed At The Root

New research in The FASEB Journal suggests that loss of skin or hair color can be corrected by a new compound -- a pseudocatalase -- that reverses oxidative stress

 Hair dye manufacturers are on notice: The cure for gray hair is coming. That's right, the need to cover up one of the classic signs of aging with chemical pigments will be a thing of the past thanks to a team of European researchers. In a new research report published online in The FASEB Journal people who are going gray develop massive oxidative stress via accumulation of hydrogen peroxide in the hair follicle, which causes our hair to bleach itself from the inside out, and most importantly, the report shows that this massive accumulation of hydrogen peroxide can be remedied with a proprietary treatment developed by the researchers described as a topical, UVB-activated compound called PC-KUS (a modified pseudocatalase). What's more, the study also shows that the same treatment works for the skin condition, vitiligo.

Hair Colors
File:Hair colors.jpg
Credit: Wikipedia

"To date, it is beyond any doubt that the sudden loss of the inherited skin and localized hair color can affect those individuals in many fundamental ways," said Karin U. Schallreuter, M.D., study author from the Institute for Pigmentary Disorders in association with E.M. Arndt University of Greifswald, Germany and the Centre for Skin Sciences, School of Life Sciences at the University of Bradford, United Kingdom. "The improvement of quality of life after total and even partial successful repigmentation has been documented."

Vitiligo
File:Vitiligo2.JPG

Credit: Wikipedia

To achieve this breakthrough, Schallreuter and colleagues analyzed an international group of 2,411 patients with vitiligo. Of that group, 57 or 2.4 percent were diagnosed with strictly segmental vitiligo (SSV), and 76 or 3.2 percent were diagnosed with mixed vitiligo, which is SSV plus non-segmental vitiligo (NSV). They found that for the first time, patients who have SSV within a certain nerval distribution involving skin and eyelashes show the same oxidative stress as observed in the much more frequent general NSV, which is associated with decreased antioxidant capacities including catalase, thioredoxin reductase, and the repair mechanisms methionine sulfoxide reductases. These findings are based on basic science and clinical observations, which led to successful patient outcomes regarding repigmentation of skin and eyelashes.

"For generations, numerous remedies have been concocted to hide gray hair," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal, "but now, for the first time, an actual treatment that gets to the root of the problem has been developed. While this is exciting news, what's even more exciting is that this also works for vitiligo. This condition, while technically cosmetic, can have serious socio-emotional effects of people. Developing an effective treatment for this condition has the potential to radically improve many people's lives."


Contacts and sources:
Cody Mooneyhan
Federation of American Societies for Experimental Biology

Special note: This report follows up on a 2009 study, which describes the cause of gray hair. See http://www.eurekalert.org/pub_releases/2009-02/foas-nla022309.php for the press release for that study, and http://www.fasebj.org/content/23/7/2065.full to access the full report.

FASEB is composed of 26 societies with more than 100,000 members, making it the largest coalition of biomedical research associations in the United States. Our mission is to advance health and welfare by promoting progress and education in biological and biomedical sciences through service to its member societies and through collaborative advocacy.

Details: Karin U. Schallreuter, Mohammed A. E. L. Salem, Sarah Holtz, and A. Panske. Basic evidence for epidermal H2O2/ONOO−-mediated oxidation/nitration in segmental vitiligo is supported by repigmentation of skin and eyelashes after reduction of epidermal H2O2 with topical NB-UVB-activated pseudocatalase PC-KUS. FASEB J doi:10.1096/fj.12-226779 ;
 

15 comments:

  1. I had vitiligo for 8 years now and I had tried different treatments (PUVA, topical steroid, meladinine cream/solution with exposure to sunlight/PUVA, oral meladinine, oil of bergamot). The vitiligo covered my neck, and one-fourth of my face. I looked for another dermatologist because i lost hope with my past dermatologists. Then somebody recommended me a good natural treatment and it worked very well. Now i'm 90% cured. With only 1 1/2 month of treatment. Watch this review, it helped me a lot: naturalvitiligotreatmentsystems.com

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  2. Thank you so much this insight was very helpful I've had Vitiligo since the age of 23 and I am now 37.

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  3. Nice post...I look forward to reading more, and getting a more active part in the talks here, whilst picking up some knowledge as well..

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  4. Faced with the question of the ideal frequency of hair wash, two clans clash: a daily washing supporters, hygienic arguments to the key, and followers of spaced shampoos, supposedly more respectful of the scalp. What is it really? Can you wash your hair every day without risk or, conversely, should space the shampoos for hair more beautiful and stronger? Decryption and pro tips.

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  5. Thats amazing it nice to know that the there is cure for grey hair and Vitiligo. There is nothing great than reversing the effect of any disease people are facing. I am really happy to know that.

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