Friday, August 26, 2011

Single Vaccine Protects Against Rabies And Ebola Virus

Researchers from Thomas Jefferson University, among other institutions, including the National Institute of Allergy and Infectious Diseases, have developed single vaccines to protect against both rabies and the Ebola virus.

Successfully tested in mice, these bivalent vaccines have several advantages over other Ebola candidates that could help speed up development for use in humans and primates. It's built on the same platform as the already approved and financially viable rabies vaccine, and it protects at-risk populations against two viruses, not just one, making it an effective and ideal public health tool.

"Many Ebola vaccine candidates have been proven effective, but none are close to licensure," said Matthias Schnell, Ph.D., director of the Jefferson Vaccine Center. "One of the challenges is the market: There's rather limited incentive in creating a vaccine for Ebola. But these vaccines could change that."

The findings were published ahead of print online August 17 in the Journal of Virology.

The Ebola virus belongs to the Filoviridae family and is comprised of five distinct species. The Zaïre, Sudan and Bundibugyo species have been associated with large Ebola hemorrhagic fever outbreaks in Africa. According to the World Health Organization, more than a thousand people have died from the virus since it was discovered in 1976.

"Rabies still poses a health threat for people worldwide, and is especially devastating in developing nations where a post exposure treatment is often not available. And Ebola still exists in parts of Central Africa and is also a chief bioterrorism concern worldwide," said Dr. Schnell, who is also a Professor in the Department of Microbiology and Immunology at Thomas Jefferson University. "You can protect these people from two very lethal diseases in an area where they don't have the best access to medical care."

The purpose of this study was to identify novel vaccine candidates for Ebola with a maximum potential of licensure and utilization.

Researchers generated a chemically inactivated and live rabies virus expressing the Ebola Zaïre species glycoprotein using a reverse genetics system based on the commonly-used rabies vaccine. Immunizations with those vaccines, the researchers found, induced immunity against each virus and conferred protection from both viruses in mice.

Piggy backing, in a sense, on the rabies vaccine could accelerate development of vaccines that protects against Ebola because of the advanced state of the rabies vaccine's safety, production and distribution, according to Schnell.

"After the vaccine has been tested in primates and eventually humans, this new vaccine could kill the proverbially two birds with one stone," he said.

There are implications for nonhumans, too—gorillas, in particular. The Ebola virus has eradicated thousands of gorillas, prompting the World Conservation Union to raise their status to "critically endangered" in 2007, the first time a mammal has become critically endangered as a direct result of disease. Vaccinations, though challenging, could stall those deaths.

What's more, several human outbreaks have been attributed to primate interaction or handling, so providing a vaccine for our closest relative could minimize that risk.

Contacts and sources:
Steve Graff
Thomas Jefferson University

3 comments:

  1. I found out, that taking herbal treatment is the best to get rid of hpv as soon as i feel the symptoms of hpv is appearing, i took the healing process by contacting Dr onokun for natural treatment it works wonders, amazingly ever since I had the herbal treatment i have not feel these horrible disease anymore and my doc told me the virus is gone, i am glad i finally got cured out from this horrible disease. every hpv or herpes patients should also get in touch with this herbalist Dr to get ride of these disease forever his email address;
    dronokunherbalcure@gmail.com..........he also specialize on the following details.

    HIV/AID
    HERPES 1/2
    CANCER

    ReplyDelete
  2. Investing online has been a main source of income,that's why knowledge plays a very important role in humanity,you don't need to over work yourself for money.All you need is the right information,and you could build your own wealth from the comfort of your home!Binary trading is dependent on timely signals,assets or controlled strategies which when mastered increases chance of winning up to 90%-100% with trading. It’s possible to earn $10,000 to $20,000 trading weekly-monthly,just file a complaint with  Robert,I had almost given up on everything about binary trading and ever getting my lost funds back,till i met with him,with his help now i have my lost funds back to my bank account and I can now trade successfully with his profitable strategies and software!! Email: Robertseaman939@gmail.com or Fb.me/investandmakemoney1 or  whatsApp: +44 7466 770724

    ReplyDelete
  3. I has suffered for Human papillomavirus HPV) for 2years, I was given some tablets at the hospital but I refused to take it, They said I have to be on it for life so I don't want take a drugs everyday for life. No point in taking medicine everyday when u won't get cure from it and I was advice to seek for natural herbal cure, after some time I found dr onokun is the most trustful herbalist that have herbs to cure wicked symptom's,I emailed dr onokun, for 2weeks been his patient he cured my (HPV) with his herbal. I only used his natural herbs for two weeks it was 100% cure. I'm not (HPV) patient anymore. I'm happy about it i finally got cured out of this mess been in my body for 2years. I also recommend you if you're living with (HPV) or herpes symptoms i also want you to be free contact dr onokun with the email attach to my post. Dronokunherbalcure@gmail.com

    ReplyDelete