Iranian surgeons implanted an artificial trachea in human body by injecting matrix cells in the throat of a 29-year-old woman in a Tehran hospital, the first such operation in the world.
Dr. Jalaloddin Ghanavy, the artificial trachea project executive, said that in this implant performed with no surgery, the fabricated trachea framework together with nanocapsules for release of growth and cellular differentiation factors were injected to damaged trachea.
He made the remarks in a news conference held for the announcement of Iranian scientists' success in artificial trachea implant by single-phase operation in human which was performed on a 29-year-old woman for the first time in the world.
"After injection of synthesized material, stem cells migrated to the framework by blood circulation and transformed to cartilaginous cells by growth factors", he added.
He reiterated that three days after the first step, a second injection containing matrix and other growth factors was given for epithelial cells which eventually resulted in repairing trachea organ on the injected framework.
According to the researchers, the next surgery plan is to transplant artificial trachea to people with such damaged trachea for whom there is no chance of repair by any kind of surgery. It is remarkable that this achievement is obtained as a result of 12 years research effort.
Also, Aliakbar Velayati, Masih Denshvari Hospital Chief, reiterated that the mentioned implant is performed for the first time in the world, saying, "This implant was performed with no need to surgery at two steps. It was performed to a sheep on 2008 which is alive now."
"It is a common practice to transplant trachea from brain dead people to patients in foreign countries. It causes immune system's reaction to the transplanted trachea and to reject it. To overcome this problem, immune system suppressing drugs with many side effects are used", he added.
The woman had traveled to foreign countries 10 years ago to mend the problem and had undergone two surgeries but unfortunately neither operation had worked for her, Velayati said.
Source: Iran Nanotechnology Initiative Council