Wednesday, March 31, 2010

Fabled "Vegetable Lamb of Tartary" Offers Hope for New Osteoporosis Treatment

This illustration from an 1887 book shows the fabled "Vegetable Lamb of Tartary," a plant once believed to ripen into a baby sheep. The plant now shows promise for treating osteoporosis.

Credit: Wikimedia Commons

The "vegetable lamb" plant — once believed to bear fruit that ripened into a living baby sheep — produces substances that show promise in laboratory experiments as new treatments for osteoporosis, the bone-thinning disease. That's the conclusion of a new study in ACS' monthly Journal of Natural Products.

Young Ho Kim and colleagues point out that osteoporosis is a global health problem, affecting up to 6 million women and 2 million men in the United States alone. Doctors know that the secret to strong bones involves a delicate balance between two types of bone cells: Osteoblasts, which build up bone, and osteoclasts, which break down bone.

Seeking potential medications that might tip the balance in favor of bone building, the researchers turned to the "vegetable lamb" plant as part of a larger study plants used in folk medicine in Vietnam. In the 16th and 17th centuries, some of the world's most celebrated scientists believed the plant (Cibotium barmoetz) fruited into a newly born lamb, which then grazed on nearby grass and weeds. Kim's group isolated compounds from C. barmoetz and showed that they blocked formation of bone-destroying osteoclasts formation in up to 97 percent of the cells in laboratory cultures without harmful effects on other cells. The substances "could be used in the development of therapeutic targets for osteoporosis," the article notes.

"Inhibitors of Osteoclast Formation from Rhizomes of Cibotium barometz"

Sources and Contacts:
Young Ho Kim, Ph.D.
Chungnam National University
Daejeon, Korea
Phone: 82-42-821-5933
Email: yhk@cnu.ac.kr

Michael Bernstein. m_bernstein@acs.org
202-872-6042. American Chemical Society

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